Evaluation of atherogenic index amoung diacetylmorphine addicts
Diacetylmorphine addiction causes multiple pathologies including increased risk of cardiovascular diseases. Atherogenic index of plasma (AIP) i-e triglycerides/high-density lipoprotein (HDL) cholesterol ratio and low density lipoprotein/high density lipoprotein (LDL/HDL) ratio are the predicting markers for cardiovascular disease. Therefore, in this study we aimed to look for atherogenic index in diacetylmorphine addicts.
This cross sectional study included forty one active male diacetylmorphine addicts with age 25 to 46 years compared with forty one normal male subjects (n=82). Assessment involved detail history and examination along with baseline laboratory tests for exclusion of infection. To calculate the atherogenic index lipid profile including total cholesterol, LDL-C, HDL-C and TG of all the subjects was done by Erba XL 200 random access clinical chemistry analyzer. Data was represented as mean ± standard deviation. Data was subjected to independent sample T test, univariate and multivariate regression analysis via Statistical Package for the Social Sciences (SPSS) version 22. p < 0.05 was considered significant.
Atherogenic index (AIP)= triglycerides/high-density lipoprotein (HDL) cholesterol ratio was non significant in both the groups (p = 0.791). However, LDL-C/HDL-C ratio was significantly lower in addicts as compare to the normal subjects (p < 0.001)
Diacetylmorphine exposure do not increase the atherogenic index as compared to normal individuals and may have beneficial effects on LDL/HDL ratio.