A Outcomes of Vancomycin Enema vs Normal Saline Enema in Patients with Hirschsprung Associated Enterocolitis

Authors

  • Muhammad Rehan Northwest General Hospital and Research Center Peshawar
  • Saman Gul Naseer Teaching Hospital Peshawar
  • Muhammad Salman Saleem Department of Pediatric Surgery Children Hospital Lahore
  • Nasim Khan Department of Pediatric Surgeon Lady Ready Hospital Peshawar
  • Khawar Saeed Northwest General Hospital and Research Center Peshawar

DOI:

https://doi.org/10.35845/abms.2024.2.351

Keywords:

Hirschsprung’s disease, Enterocolitis, Vancomycin, Normal Saline Enema

Abstract

OBJECTIVE: This research was designed to compare the outcomes of vancomycin enema and normal saline enema in the treatment of HAEC in terms of full remission of symptoms of HAEC and length of hospital stay.

METHODOLOGY: This randomized controlled trial was carried out from March 2020 to March 2021 in the Department of Pediatric Surgery at Lady Reading Hospital Peshawar. A total of 40 patients were randomly assigned in two groups; A (vancomycin enema) and B (normal saline enema), with 20 patients in each group. After the diagnosis was established, patients were randomly assigned to one of two groups by balloting method. SPSS 24 was used for data entry and analysis

RESULTS: In our research, males outnumbered females. In both groups, the HAEC score decreased significantly after treatment from pre-treatment scores (12.31 and 11.15) to post-treatment scores (7.73 and 7.61) with significant p --values 0.013 & 0.015 respectively. The average hospital stay between vancomycin enema and normal saline enema group was 7.91 days as opposed to 6.89 days with a p-value (0.031). Overall, 7.33 ± 2.426 days were required for full remission of HAEC symptoms in the study. A p-value of 0.251 suggested that there was no difference between groups in terms of symptom relief

CONCLUSION: We conclude that there is no difference between the normal saline and vancomycin enema in terms of symptom resolution and hospital stay in patients of HAEC.

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Published

2024-12-28

How to Cite

1.
Rehan M, Gul S, Saleem MS, Khan N, Saeed K. A Outcomes of Vancomycin Enema vs Normal Saline Enema in Patients with Hirschsprung Associated Enterocolitis . Adv Basic Med Sci [Internet]. 2024Dec.28 [cited 2026Jan.8];8(2):68-73. Available from: https://abms.kmu.edu.pk/index.php/abms/article/view/351

Issue

Vol. 8 No. 2 (2024): (July-December) Advances in Basic Medical Sciences

Section

Original Articles

License

Copyright (c) 2025 Muhammad Rehan, Saman Gul, Muhammad Salman Saleem, Nasim Khan, Khawar Saeed

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