Lower Calciferol Level In Diabetic People And Their Association With Glycated Haemoglobin

Authors

  • Rizwana Kalsoom Paharpur hospital Dera Ismail Khan
  • Muhammad Rehan Khan Cardiology Unit, DHQ Hospital Dera Ismail Khan
  • Saima Umer Mufti Memorial hospital DIKhan
  • Shahjahan Ustrana Department of Biochemistry, Gomal Medical College, Dera Ismail Khan
  • Irshad Ahmed Gomal Medical College D.I. Khan
  • Farhana Kalsoom Wensam College, Dera Ismail Khan

DOI:

https://doi.org/10.35845/abms.2024.1.298

Keywords:

Calciferol, Adult Onset Diabetes Mellitus, Glycated haemoglobin, diabetes, vitamin D

Abstract

Objective

To investigate the relationship between low calciferol levels and glycated hemoglobin in diabetics with normal blood sugar control.

Methods                                                            

Vitamin D (calciferol) levels and HbA1c levels were examined in 110 individuals with type 2 diabetes and a control group, ensuring both groups were similar in terms of gender and age. Calciferol (25(OH)D3) level was determined using the method of radioimmunoassay (RIA) and the High-performance liquid chromatography technique (HPLC) was used to determine the glycosylated hemoglobin (HbA1c) level.

Results

Calciferol levels were found low in the test group (type 2 diabetic patients) 18.16 ± 0.85 ng/ml as compared to the control group 24.38 ±2.01ng/ml with (p≤0.000). The calciferol levels were assessed and it was found that they were inversely related to glycated hemoglobin levels in the test group (r (2) = 0.047, linear regression, p ≤ 0.009,). Calciferol levels were also inversely associated with glycated hemoglobin levels in combined analyzed data of test and control groups (p ≤ 0.001, r (2) = 0.079).

Conclusion

The study determined that the calciferol levels were found with decreased frequency in the diabetic group as compared to the control group and it showed that vitamin D levels have a key role in glycemic control in type 2 diabetic patients. These findings support the idea that type 2 diabetic patients may improve their glycemic control by using vitamin D supplementation.

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Published

2024-06-21

How to Cite

1.
Kalsoom R, Khan MR, Umer S, Ustrana S, Ahmed I, Kalsoom F. Lower Calciferol Level In Diabetic People And Their Association With Glycated Haemoglobin. Adv Basic Med Sci [Internet]. 2024Jun.21 [cited 2026Feb.12];8(1):12-6. Available from: https://abms.kmu.edu.pk/index.php/abms/article/view/298

Issue

Vol. 8 No. 1 (2024): Advances in Basic Medical Sciences

Section

Original Articles

License

Copyright (c) 2024 Rizwana Kalsoom, Muhammad Rehan Khan, Saima Umer, Shahjahan Ustrana, Irshad Ahmed, Farhana Kalsoom

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