Lower Calciferol Level In Diabetic People And Their Association With Glycated Haemoglobin

Authors

  • Rizwana Kalsoom Paharpur hospital Dera Ismail Khan
  • Muhammad Rehan Khan Cardiology Unit, DHQ Hospital Dera Ismail Khan
  • Saima Umer Mufti Memorial hospital DIKhan
  • Shahjahan Ustrana Department of Biochemistry, Gomal Medical College, Dera Ismail Khan
  • Irshad Ahmed Gomal Medical College D.I. Khan
  • Farhana Kalsoom Wensam College, Dera Ismail Khan

DOI:

https://doi.org/10.35845/abms.2024.1.298

Keywords:

Calciferol, Adult Onset Diabetes Mellitus, Glycated haemoglobin, diabetes, vitamin D

Abstract

Objective

To investigate the relationship between low calciferol levels and glycated hemoglobin in diabetics with normal blood sugar control.

Methods                                                            

Vitamin D (calciferol) levels and HbA1c levels were examined in 110 individuals with type 2 diabetes and a control group, ensuring both groups were similar in terms of gender and age. Calciferol (25(OH)D3) level was determined using the method of radioimmunoassay (RIA) and the High-performance liquid chromatography technique (HPLC) was used to determine the glycosylated hemoglobin (HbA1c) level.

Results

Calciferol levels were found low in the test group (type 2 diabetic patients) 18.16 ± 0.85 ng/ml as compared to the control group 24.38 ±2.01ng/ml with (p≤0.000). The calciferol levels were assessed and it was found that they were inversely related to glycated hemoglobin levels in the test group (r (2) = 0.047, linear regression, p ≤ 0.009,). Calciferol levels were also inversely associated with glycated hemoglobin levels in combined analyzed data of test and control groups (p ≤ 0.001, r (2) = 0.079).

Conclusion

The study determined that the calciferol levels were found with decreased frequency in the diabetic group as compared to the control group and it showed that vitamin D levels have a key role in glycemic control in type 2 diabetic patients. These findings support the idea that type 2 diabetic patients may improve their glycemic control by using vitamin D supplementation.

References

Povaliaeva A, Pigarova E, Zhukov A, Bogdanov V, Dzeranova L, Mel’nikova O, Pekareva E, Malysheva N, Ioutsi V, Nikankina L, Rozhinskaya L. Evaluation of vitamin D metabolism in patients with type 1 diabetes mellitus in the setting of cholecalciferol treatment. Nutrients. 2020 Dec 18;12(12):3873.

El Lithy A, Abdella RM, El-Faissal YM, Sayed AM, Samie RM. The relationship between low maternal serum vitamin D levels and glycemic control in gestational diabetes assessed by HbA1c levels: an observational cross-sectional study. BMC pregnancy and childbirth. 2014 Dec;14:1-6.

George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis. Diabetic medicine. 2012 Aug;29(8):e142-50.

Szymczak-Pajor I, Śliwińska A. Analysis of association between vitamin D deficiency and insulin resistance. Nutrients. 2019 Apr 6;11(4):794.

Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Reviews in Endocrine and Metabolic Disorders. 2017 Jun;18:153-65.

Siddiqee MH, Bhattacharjee B, Siddiqi UR, MeshbahurRahman M. High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis. BMC Public Health. 2021 Dec;21:1-8.

Baxter JA, Wasan Y, Hussain A, Soofi SB, Ahmed I, Bhutta ZA. Characterizing Micronutrient status and risk factors among late adolescent and young women in rural Pakistan: A cross-sectional assessment of the Mapps trial. Nutrients. 2021 Apr 9;13(4):1237.

Ponmalar P. Effect of Serum 25 Hydroxy Cholecalciferol on Glycemic Status and Lipid Profile in Type 2 Diabetes Mellitus (Doctoral dissertation, Kilpauk Medical College, Chennai) 2019.

Palomer X, González‐Clemente JM, Blanco‐Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes, Obesity, and Metabolism. 2008 Mar;10(3):185-97.

Lau SL, Gunton JE, Athayde NP, Byth K, Cheung NW. Serum 25‐hydroxyvitamin D and glycated hemoglobin levels in women with gestational diabetes mellitus. Medical journal of Australia. 2011 Apr;194(7):334-7.

Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O’Beirne M, Rabi DM. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. Bmj. 2013 Mar 26;346.

Hoxha M, Zoto M, Deda L, Vyshka G. Vitamin D and its role as a protective factor in allergy. International scholarly research notices. 2014;2014(1):951946.

Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmunity reviews. 2007 Nov 1;7(1):59-64.

Tai K, Need AG, Horowitz M, Chapman IM. Glucose tolerance and vitamin D: effects of treating vitamin D deficiency. Nutrition. 2008 Oct 1;24(10):950-6.

Guasch A, Bulló M, Rabassa A, Bonada A, Del Castillo D, Sabench F, Salas-Salvadó J. Plasma vitamin D, and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study. Cardiovascular diabetology. 2012 Dec;11:1-1.

Indhavivadhana S, Boonyachan W, Rattanachaiyanont M, Wongwananuruk T, Techatraisak K, Sa-Nga-Areekul N. Effectiveness of vitamin D2 supplementation on high-sensitivity C-reactive protein and other metabolic indices in menopausal Thai women: a randomized controlled trial. Gynecological Endocrinology. 2022 Jan 2;38(1):83-9.

Melguizo-Rodríguez L, Costela-Ruiz VJ, García-Recio E, De Luna-Bertos E, Ruiz C, Illescas-Montes R. Role of vitamin D in the metabolic syndrome. Nutrients. 2021 Mar 3;13(3):830.

Mozos I, Marginean O. Links between vitamin D deficiency and cardiovascular diseases. BioMed research international. 2015;2015(1):109275.

Brown AC. Kidney toxicity related to herbs and dietary supplements: Online table of case reports. Part 3 of 5 series. Food and Chemical Toxicology. 2017 Sep 1;107:502-19.

Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence. Autoimmunity reviews. 2013 Aug 1;12(10):976-89.

Szymczak-Pajor I, Miazek K, Selmi A, Balcerczyk A, Śliwińska A. The action of vitamin D in adipose tissue: is there the link between vitamin D deficiency and adipose tissue-related metabolic disorders?. International Journal of Molecular Sciences. 2022 Jan 16;23(2):956.

Park CY, Han SN. The role of vitamin D in adipose tissue biology: adipocyte differentiation, energy metabolism, and inflammation. Journal of Lipid and Atherosclerosis. 2021 May;10(2):130.

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Published

2024-06-21

How to Cite

1.
Kalsoom R, Khan MR, Umer S, Ustrana S, Ahmed I, Kalsoom F. Lower Calciferol Level In Diabetic People And Their Association With Glycated Haemoglobin. Adv Basic Med Sci [Internet]. 2024Jun.21 [cited 2024Nov.3];8(1):12-6. Available from: https://abms.kmu.edu.pk/index.php/abms/article/view/298