Lower Calciferol Level In Diabetic People And Their Association With Glycated Haemoglobin
DOI:
https://doi.org/10.35845/abms.2024.1.298Keywords:
Calciferol, Adult Onset Diabetes Mellitus, Glycated haemoglobin, diabetes, vitamin DAbstract
Objective
To investigate the relationship between low calciferol levels and glycated hemoglobin in diabetics with normal blood sugar control.
Methods
Vitamin D (calciferol) levels and HbA1c levels were examined in 110 individuals with type 2 diabetes and a control group, ensuring both groups were similar in terms of gender and age. Calciferol (25(OH)D3) level was determined using the method of radioimmunoassay (RIA) and the High-performance liquid chromatography technique (HPLC) was used to determine the glycosylated hemoglobin (HbA1c) level.
Results
Calciferol levels were found low in the test group (type 2 diabetic patients) 18.16 ± 0.85 ng/ml as compared to the control group 24.38 ±2.01ng/ml with (p≤0.000). The calciferol levels were assessed and it was found that they were inversely related to glycated hemoglobin levels in the test group (r (2) = 0.047, linear regression, p ≤ 0.009,). Calciferol levels were also inversely associated with glycated hemoglobin levels in combined analyzed data of test and control groups (p ≤ 0.001, r (2) = 0.079).
Conclusion
The study determined that the calciferol levels were found with decreased frequency in the diabetic group as compared to the control group and it showed that vitamin D levels have a key role in glycemic control in type 2 diabetic patients. These findings support the idea that type 2 diabetic patients may improve their glycemic control by using vitamin D supplementation.
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Copyright (c) 2024 Rizwana Kalsoom, Muhammad Rehan Khan, Saima Umer, Shahjahan Ustrana, Irshad Ahmed, Farhana Kalsoom
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