Understanding the Link Between Consanguineous Marriage and Pathological and Non-pathological Short Stature: A Clinical Investigation

Authors

  • Marya Hameed National Institute of Child Health, Karachi, Pakistan.
  • Sumera Mahar National Institute of Rehabilitation Medicine, Islamabad, Pakistan.
  • Fahad Hassan Sheikh National Institute of Child Health, Karachi, Pakistan.
  • Fatima Siddiqui National Institute of Child Health, Karachi, Pakistan.
  • Muhammad Khuzzaim Khan Dow University of Health Sciences, Karachi, Pakistan.
  • Bushra Admani Dow University of Health Sciences, Karachi, Pakistan.

DOI:

https://doi.org/10.35845/abms.2024.1.284

Keywords:

Stunted growth; growth failure; nutrition; genetics; consanguinity

Abstract

Objective

To investigate the associations between consanguinity and clinical factors among patients with short stature and to determine whether consanguineous marriage is associated with an increased risk for dysplastic and storage disorders among patients with short stature.

Methods

 This study adopted a retrospective cohort design to investigate common features and potential causes of short stature, specifically focusing on skeletal survey findings. Using a convenience sample of 460 patients, 62% of parents reported consanguineous marriage. The participants were evaluated for clinical factors such as pathological short stature, head size abnormalities, and other related conditions. Data was collected from the medical records of a large tertiary care hospital. Statistical analysis was performed using SPSS 26 software.

RESULTS

The median age at presentation was 3 years, with a slight skew towards older ages. Males comprised 62.4% of the participants. Notably, 43% of patients had normal short stature, meaning no underlying cause was identified. The remaining patients had pathological short stature caused by various conditions: Metabolic disorders (16.1%), Storage disorders (13.3%), and Dysplastic disorders (18.5%).

CONCLUSION

The findings suggest that consanguineous marriage is associated with an increased risk for dysplastic and storage disorders. This highlights the need for public health policies and interventions aimed at reducing the prevalence of these conditions in communities where consanguineous marriage is common. Further research is needed to investigate the underlying mechanisms linking consanguineous marriage to health outcomes such as short stature and to develop effective interventions to mitigate the negative impacts of this cultural practice on health.

Author Biographies

Marya Hameed, National Institute of Child Health, Karachi, Pakistan.

Department of Radiology

Sumera Mahar, National Institute of Rehabilitation Medicine, Islamabad, Pakistan.

Department of Radiology

Fahad Hassan Sheikh, National Institute of Child Health, Karachi, Pakistan.

Department of Radiology

Fatima Siddiqui, National Institute of Child Health, Karachi, Pakistan.

Department of Radiology

Muhammad Khuzzaim Khan, Dow University of Health Sciences, Karachi, Pakistan.

Department of Internal Medicine

Bushra Admani, Dow University of Health Sciences, Karachi, Pakistan.

Department of Paediatrics

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Published

2024-06-21

How to Cite

Hameed, M., Mahar, S., Sheikh, F. H., Siddiqui, F., Khan, M. K., & Admani, B. (2024). Understanding the Link Between Consanguineous Marriage and Pathological and Non-pathological Short Stature: A Clinical Investigation. ADVANCES IN BASIC MEDICAL SCIENCES, 8(1), 08–11. https://doi.org/10.35845/abms.2024.1.284