Association between sectorial retinal nerve fiber layer thickness with anatomical variables of Lamina Cribrosa- A comparative study

Authors

  • Ayesha Saba Naz Bahria University Medical and Dental College, Karachi Pakistan
  • Aisha Qamar Bahria University Health Sciences, Karachi Pakistan
  • Ambreen Surti Bahria University Health Sciences, Karachi Pakistan
  • Yasmeen Mahar Bahria University Health Sciences, Karachi Pakistan

DOI:

https://doi.org/10.35845/abms.2023.2.218

Abstract

Objective: To compare sectorial retinal nerve fiber layer thickness (RNFLT) with anterior Lamina Cribrosa depth (ALCD) and Lamina Cribrosa thickness (LCT) in primary open-angle glaucoma (POAG) cases and healthy age-matched controls

Methods: This case-control study was conducted at Al-Ain Eye Institute, Karachi from November 2018 till February 2019. Senior ophthalmologist recruited 57 POAG cases and 46 age-matched healthy controls. Calculation of intraocular pressure (IOP) and open angle carried out using Goldmann tonometry and Slit-lamp biomicroscopy with stereoscopic ophthalmoscopy respectively. Extremely precise spectral domain ocular coherence tomography with enhanced depth imaging (EDI-OCT) utilized to determine ALCD, LCT and RNFLT.

Results: RNFLT in various sectorial regions displayed statistically significant results (p-value of 0.001) when compared with controls. Superior retinal sector revealed the highest ranges of thickness (75.50 ± 9.64 µm), while thin retina was observed in global measurements (48.40 ± 0.84 µm). Enhanced ALCD was seen (545.50 ± 3.53 µm) among 15 POAG cases. Least thickness of LCT documented in the four POAG cases in inferior retinal sector (204.57 ± 79.04 µm).

Conclusion: Assessments of RNFLT, ALCD and LCT provides valuable knowledge that can be utilized for the management and predicting the course and prognosis of POAG.

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Published

2023-12-31

How to Cite

1.
Saba Naz A, Qamar A, Surti A, Mahar Y. Association between sectorial retinal nerve fiber layer thickness with anatomical variables of Lamina Cribrosa- A comparative study. Adv Basic Med Sci [Internet]. 2023Dec.31 [cited 2026Jan.23];7(2):35-8. Available from: https://abms.kmu.edu.pk/index.php/abms/article/view/218

Issue

Vol. 7 No. 2 (2023): Advances in Basic Medical Sciences

Section

Original Articles

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Copyright (c) 2024 Ayesha Saba Naz, Aisha Qamar , Ambreen Surti , Yasmeen Mahar

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