Association between sectorial retinal nerve fiber layer thickness with anatomical variables of Lamina Cribrosa- A comparative study


  • Ayesha Saba Naz Naz Bahria University Medical and Dental College, Karachi
  • Aisha Qamar Bahria University Health Sciences, Karachi
  • Ambreen Surti Bahria University Health Sciences, Karachi
  • Yasmeen Mahar Bahria University Health Sciences, Karachi



Objective: To compare sectorial retinal nerve fiber layer thickness (RNFLT) with anterior Lamina Cribrosa depth (ALCD) and Lamina Cribrosa thickness (LCT) in primary open-angle glaucoma (POAG) cases and healthy age-matched controls

Methods: This case-control study was conducted at Al-Ain Eye Institute, Karachi from November 2018 till February 2019. Senior ophthalmologist recruited 57 POAG cases and 46 age-matched healthy controls. Calculation of intraocular pressure (IOP) and open angle carried out using Goldmann tonometry and Slit-lamp biomicroscopy with stereoscopic ophthalmoscopy respectively. Extremely precise spectral domain ocular coherence tomography with enhanced depth imaging (EDI-OCT) utilized to determine ALCD, LCT and RNFLT.

Results: RNFLT in various sectorial regions displayed statistically significant results (p-value of 0.001) when compared with controls. Superior retinal sector revealed the highest ranges of thickness (75.50 ± 9.64 µm), while thin retina was observed in global measurements (48.40 ± 0.84 µm). Enhanced ALCD was seen (545.50 ± 3.53 µm) among 15 POAG cases. Least thickness of LCT documented in the four POAG cases in inferior retinal sector (204.57 ± 79.04 µm).

Conclusion: Assessments of RNFLT, ALCD and LCT provides valuable knowledge that can be utilized for the management and predicting the course and prognosis of POAG.


Bertaud S, Aragno V, Baudouin C, Labbé A. Primary open-angle glaucoma. Rev Med Interne. 2019 Jul 1; 40(7): 445-52.

Kang JM, Tanna AP. Glaucoma. Med Clin North Am. 2021 May 2; 105(3): 493-510. doi: 10.1016/j.mcna.2021.01.004. Epub 2021 Apr 2. PMID: 33926643.

Sarfraz, M. H., Mehboob, M. A., Ul Haq, R. I. (2017). Correlation between central corneal thickness and visual field defects, cup to disc ratio and retinal nerve fiber layer thickness in primary open angle glaucoma patients. Pak. J. Med. Sci. 2017 Feb; 33(1), 132. doi: 10.12669/pjms.331.11623

Barnard S. Primary open angle glaucoma. 2019 (

Lee EJ, Kim TW, Kim H, Lee SH, Girard MJA, Mari JM. Comparison between Lamina Cribrosa Depth and Curvature as a Predictor of Progressive Retinal Nerve Fiber Layer Thinning in Primary Open-Angle Glaucoma. Ophthalmol Glaucoma. 2018 Aug; 1(1): 44-51. doi: 10.1016/j.ogla.2018.05.007. Epub 2018 Jun 29. PMID: 32672632.

Krzyżanowska-Berkowska P, Czajor K, Helemejko I, Iskander DR. Relationship between the rate of change in lamina cribrosa depth and the rate of retinal nerve fiber layer thinning following glaucoma surgery. PloS one. 2018 Nov 6; 13(11):e0206040.

Won HJ, Sung KR, Shin JW, Jo YH, Song MK. Comparison of Lamina Cribrosa Curvature in Pseudoexfoliation and Primary Open-Angle Glaucoma. Am. J. Ophthalmol. 2021 Mar 1; 223:1-8.

Tan NY, Koh V, Girard MJ, Cheng CY. Imaging of the lamina cribrosa and its role in glaucoma: a review. Clin Exp Ophthalmol. 2018 Mar; 46(2):177-88.

Sirakaya E, Kucuk B. Thickness of the lamina cribrosa, retinal-nerve fiber layer, and peripapillary choroid in patients with branch retinal vein occlusion. Ophthalmologica. 2020; 243(4):288-96.

Saba A, Usmani A, Islam QU, Assad T. Unfolding the enigma of lamina cribrosa morphometry and its association with glaucoma. Pak. J. Med. Sci. 2019 Nov; 35(6):1730.

Kim JA, Kim TW, Weinreb RN, Lee EJ, Girard MJ, Mari JM. Lamina cribrosa morphology predicts progressive retinal nerve fiber layer loss in eyes with suspected glaucoma. Sci. Rep. 2018 Jan 15;8(1):1-0.

Kim, Y. W., Jeoung, J. W., Girard, M. J., Mari, J. M., Park, K. H., Kim, D. M. (2016). Clinical assessment of lamina cribrosa curvature in eyes with primary open-angle glaucoma. PloS one, 11(3), e0150260.

Naz AS, Qamar A, Haque SU, Zaman Y, Faheem F. Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma. Pak. J. Med. Sci. 2020 Mar;36 (3):521-525.

Chen A, Cheng YC, Lai HY, Lin PW, Wu PC, Kuo MT, Lai C. The severity of visual field defect and the defective angles of localized retinal nerve fiber layer using a novel approach. J Formos Med Assoc. 2021 Dec 1; 120(12):2153-9.

Won HJ, Sung KR, Shin JW, Jo YH, Song MK. Comparison of Lamina Cribrosa Curvature in Pseudoexfoliation and Primary Open-Angle Glaucoma. Am. J. Ophthalmol.. 2021 Mar 1; 223:1-8.

Parikh R, Kitnarong N, Jonas JB, Parikh SR, Thomas R. Optic disc morphology in primary open-angle glaucoma versus primary angle-closure glaucoma in South India. Indian J. Ophthalmol. 2021 Jul; 69(7):1833.

Wu J, Du Y, Li J, Fan X, Lin C, Wang N. The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication. Sci. Rep. 2021 May 7; 11(1):1-3.

Alexopoulos P, Fernandes AG, Ghassabi Z, Zambrano R, Lee T, Vellappally A, et al. Lamina Cribrosa Microstructure in Non-Human Primates with Naturally Occurring Peripapillary Retinal Nerve Fiber Layer Thinning. Investig. Ophthalmol. Vis. Sci. 2022 Jun 1; 63(7):932-A0401.

Jnawali A, Mirhajianmoghadam H, Musial G, Porter J, Ostrin LA. The optic nerve head, lamina cribrosa, and nerve fiber layer in non-myopic and myopic children. Exp. Eye Res. 2020 Jun 1; 195:108041.

Wong BJ, Moghimi S, Zangwill LM, Christopher M, Belghith A, Ekici E, et al. Relationship of Corneal Hysteresis and Anterior Lamina Cribrosa Displacement in Glaucoma. Am J Ophthalmol. 2020 Apr; 212:134-143. doi: 10.1016/j.ajo.2019.11.017

Boqoaied FA, Fahmy RM, Al-Hazzaa SA, Qadi N. The Retinal Nerve Fiber Layer Thickness in Patients with Alzheimer’s Disease. Saudi J Med. 2020 Feb 26; 5(2): 113-129




How to Cite

Naz, A. S. N., Qamar , A. ., Surti , A. ., & Mahar , Y. . (2023). Association between sectorial retinal nerve fiber layer thickness with anatomical variables of Lamina Cribrosa- A comparative study. ADVANCES IN BASIC MEDICAL SCIENCES, 7(2), 32–35.