https://abms.kmu.edu.pk/index.php/abms/issue/feed Advances in Basic Medical Sciences 2021-08-19T14:54:50+00:00 Dr. Najma Baseer abms@kmu.edu.pk Open Journal Systems <center> <h1><strong>The Official Journal of Institute of Basic Medical Sciences</strong> </h1> <h1><strong>Khyber Medical University, Peshawar, Pakistan.</strong></h1> <p> </p> <p><strong>ABMS</strong> is a Bi-Annual Journal of Innovations &amp; Advances in Basic Medical Sciences. The Journal aims to add significant medical literature for the improvement in the field of medicine. The Journal provides Swift, Affordable, Prompt, Open Access and Blind Peer-Reviewed &amp; Editorial Reviewed Publications.</p> <p class="p1">The International Centre for the registration of serial publications (CIEPS – ISSN International Centre), located in Paris 75003 (France), 45 rue de Turbigo, certifies that <strong>ISSN Print <a href="https://portal.issn.org/resource/ISSN/2706-7041#" target="_blank" rel="noopener">2706-7041</a></strong> and <strong>ISSN</strong> <strong>Online</strong> <a title="ISSN online" href="https://portal.issn.org/resource/ISSN/2706-7041#" target="_blank" rel="noopener"><strong>2410-6283</strong></a> are assigned to ABMS. It is also Indexed by the <strong>Directory of Open Access Scholarly Resources</strong> (ROAD).</p> <p class="p1"><strong>ABMS is in line with the standards of ICMJE (International Committee of Medical Journal Editors) and is a Member of ICMJE <a href="http://www.icmje.org/journals-following-the-icmje-recommendations/" target="_blank" rel="noopener">www.icmje.org</a> | <sub>Hosted by</sub> <a href="http://www.annals.org/" target="_blank" rel="noopener">Annals of Internal Medicine</a> / <a href="http://www.acponline.org/" target="_blank" rel="noopener">American College of Physicians</a>, USA.</strong></p> <p class="p1">The Journal routinely screen article submissions for plagiarism and uses the academic software Turnitin for this purpose and takes editorial decision to reject the submission if the plagiarism (Similarity Index) is more than 18% (Overall) or more than 5% from a single source.</p> <p>Authors are required to pay a fair manuscript handling fee for the processing of their articles. However, there are no submission charges. Authors are required to make payment only after their manuscripts have been accepted for publication. The Journal's policy is to provide a 50% discount on publication fees for authors belonging to low-income (<a href="https://www.research4life.org/access/eligibility/#groupa" target="_blank" rel="noopener">Hinari Group A</a>) countries and can't afford the fee.</p> <p>The Journal uses LOCKSS, CLOCKSS and PKP PN archival system for Long-term preservation of the Journal metadata archiving.</p> <p class="p1">Copyright (c) 2020 ABMS <a href="https://creativecommons.org/licenses/by-sa/4.0/" target="_blank" rel="license noopener"><img src="https://thestetho.com/public/site/images/shamir/80x15.png" alt="Creative Commons License" width="80" height="15" /></a>. This work is licensed under a <a href="https://creativecommons.org/licenses/by-sa/4.0/" rel="license">Creative Commons Attribution-ShareAlike 4.0 International License</a>.</p> </center> https://abms.kmu.edu.pk/index.php/abms/article/view/186 COVID19 and cell mediated immunity; the missing link of disease severity 2021-08-19T14:54:49+00:00 Muhammad Omar Malik omarmalik786@gmail.com Syed Hamid Habib dr.hamidhabib@gmail.com <p>COVID19 and cell mediated immunity; the missing link of disease severity</p> 2021-08-19T00:00:00+00:00 Copyright (c) 2021 Advances in Basic Medical Sciences https://abms.kmu.edu.pk/index.php/abms/article/view/181 Effect of Academic Stress on Physiological and Biochemical Parameters among Medical Students 2021-08-19T14:54:50+00:00 Kinza Sammar kinza.sammar@hotmail.com Inayat Shah shah.inayat@yahoo.com Maheen Shah manoshah1234@gmail.com Raeesa naz raisakhan660@gmail.com usman nazir drusmannazir.awan@gmail.com <p><span class="fontstyle0"><strong>Objective</strong><br></span><span class="fontstyle1">The primary aim of this study was to understand the effects of a stressed academic<br>environment in medical students through evaluating different physical and biochemical<br>parameters.<br></span><span class="fontstyle0"><strong>Methodology</strong><br></span><span class="fontstyle1">This study is longitudinal and based on a convenient sampling method, including 50 volunteer<br>medical students of Ayub Medical College, Abbottabad with mean age 21-25yrs (24±1) in both<br>stressed and unstressed states. Physical and biochemical parameters were evaluated by measuring<br>serum Cortisol and plasma Serotonin levels by using ELISA kits. Data were analyzed by using SPSS-<br>22.<br></span><span class="fontstyle0"><strong>Results</strong><br></span><span class="fontstyle1">Results showed an insignificant difference of Serum Cortisol (6.6±4.2ug/dl) in stressed and<br>(7.0±4.7ug/dl) unstressed states with (p=0.72). , plasma serotonin values in stressed<br>(149±140ng/ml) and unstressed (125±108ng/ml) with (p =.47) Parameters like blood pressure (both<br>systolic and diastolic) with a p-value of &lt;.01 showed significant difference during the examination.<br>However, other variables like Age, Height, Weight, BMI (p= .946), Heart Rate (p= .149) showed no<br>significant difference.<br></span><span class="fontstyle0"><strong>Conclusion</strong><br></span><span class="fontstyle1">The study concludes that little to moderate levels of changes of serum cholesterol and plasma<br>serotonin values may occur due to the academic pressure on students, which can affect their<br>professional capabilities<br></span><span class="fontstyle0"><strong>Key words</strong><br></span><span class="fontstyle1">Academic stress, Body Mass Index, Serum Cortisol, Plasma Serotonin, ELISA</span></p> <p>&nbsp;</p> 2021-08-19T00:00:00+00:00 Copyright (c) 2021 Advances in Basic Medical Sciences https://abms.kmu.edu.pk/index.php/abms/article/view/161 Upper Respiratory Allergic Symptoms And Effects Of Coal Dust On Pulmonary Function Tests Of Individuals Working In Coal Mines, Near Quetta, Baluchistan, Pakistan 2021-08-19T14:54:50+00:00 Zafar Ahmad Khan zakhan70@yahoo.co.uk Muhammad Imran Aslam zakhan70@yahoo.co.uk Muhammad Hashir Ahmad zakhan70@yahoo.co.uk Muhammad Tayyab Ahmad zakhan70@yahoo.co.uk Hajira Ishaq zakhan70@yahoo.co.uk Zahoor Ahmed zakhan70@yahoo.co.uk <p><strong> <span class="fontstyle0">Objective<br></span></strong><span class="fontstyle1">This research was carried in order to know hazardous outcomes of coal mine dust on upper<br>respiratory system and their pulmonary function tests.<br></span><span class="fontstyle0"><strong>Methodology</strong><br></span><span class="fontstyle1">In this longitudinal cross sectional study, we evaluated upper respiratory allergic symptoms and<br>pulmonary function tests deterioration cause by coal dust exposure in coal mines workers near<br>Quetta, Baluchistan (from October 2018 to March 2019). A total of 336 individuals working in coal<br>mines meeting the preset selection criteria were selected and 41 normal healthy individuals of<br>same age and sex were selected from the general public of the same region who had never been<br>exposed to coal dust/coal mines and served as control group.<br></span><span class="fontstyle0"><strong>Results</strong><br></span><span class="fontstyle1">Their pulmonary functions were recorded by (SX MULTI SPIRO, USA) and for the analysis of<br>data SPSS version 18 was employed. The result shown in frequency and percentages, Chi<br>Square test was used and </span><span class="fontstyle3">p </span><span class="fontstyle1">value of &lt; 0.05 was considered as significant.<br></span><span class="fontstyle0"><strong>Conclusion</strong><br></span><span class="fontstyle1">Unprotected exposure to coal dust for longer period of time has bad impact on pulmonary<br>function test and biochemical parameters and is associated with increased frequency of upper<br>respiratory tract allergic symptoms.<br></span><span class="fontstyle0"><strong>Key words</strong><br></span><span class="fontstyle1">Quetta, Coal mine, Pulmonary Function Test, Microspheres</span></p> 2021-08-19T00:00:00+00:00 Copyright (c) 2021 Advances in Basic Medical Sciences https://abms.kmu.edu.pk/index.php/abms/article/view/183 Analysis of Caesarean Section Rates in a Tertiary Care Hospital through Robson's Ten Group Classification System (RTGCS) 2021-08-19T14:54:50+00:00 Rubina Akhtar rubiktk@hotmail.com Ghazala Shams ghazalaamin73.ga@gmail.com Madiha Iqbal drmadiha881@gmail.com Basharat Ahmed basharata231@gmail.com Zara Alam Jan zahralamjan1992@gmail.com Aisha Nawaz irshadibms@kmu.edu.pk <p><span class="fontstyle0"><strong>Objective</strong><br></span><span class="fontstyle1">To analyse the trend of caesarean sections at a tertiary care hospital according to Robson’s Ten<br>Group Classification System<br></span><span class="fontstyle0"><strong>Methodology</strong><br></span><span class="fontstyle1">This retrospective study was conducted at the department of obstetrics and gynecology Unit “B”<br>Hayatabad Medical Complex, Peshawar from January to December 2019.<br>Data for all births including live births and stillbirths by C-section (n=1538) was extracted from<br>the patient’s record and grouped into Robson’s 10 categories. Data was analyzed using<br>descriptive statistics and the outcome expressed as frequencies and percentages.<br></span><span class="fontstyle0"><strong>Results</strong><br></span><span class="fontstyle1">During the study period, 5609 women were delivered in this hospital. The overall cesarean section<br>was 27.42%. The leading contributor to the overall cesarean section rate was group 5 i.e. women<br>with previous cesarean section, the contribution being 6.63% of the overall 27.42%.<br></span><span class="fontstyle0"><strong>Conclusion</strong><br></span><span class="fontstyle1">The Robson classification is an effective tool to identify the areas/factors which significantly<br>contribute to the high C-section rate and accordingly provide basis to formulate strategies aimed<br>to decrease the C-section rate.<br></span><span class="fontstyle0"><strong>Key words</strong><br></span><span class="fontstyle1">Caesarean section, Robson’s Ten Group Classification System</span></p> 2021-08-19T00:00:00+00:00 Copyright (c) 2021 Advances in Basic Medical Sciences https://abms.kmu.edu.pk/index.php/abms/article/view/163 One-Year Histopathological Audit of Thyroid Lesions at Tertiary Care Hospital of Peshawar 2021-08-19T14:54:50+00:00 Mir Attaullah mirattaullah9@gmail.com Hamid Ullah Shah mirattaullah9@gmail.com <p><span class="fontstyle0"><strong>Objective</strong><br></span><span class="fontstyle1">To know the number of various thyroid lesions both neoplastic and non-neoplastic in a tertiary<br>care hospital of Peshawar.<br></span><span class="fontstyle0"><strong>Methodology</strong><br></span><span class="fontstyle1">It was a retrospective record-based study conducted at Lady reading Hospital (LRH) Peshawar<br>Khyber Pakhtunkhwa. Histopathological reports of all the thyroidectomy specimens received from<br>1</span><span class="fontstyle1">st </span><span class="fontstyle1">January 2019 to 31</span><span class="fontstyle1">st </span><span class="fontstyle1">December 2019 in the Department of Pathology were included in this study.<br>Data regarding patient’s age, sex, type of thyroidectomy and histopathological diagnosis was<br>collected from the record of the laboratory, recorded into Microsoft excel and analyzed by statistical<br>methods.<br></span><span class="fontstyle0"><strong>Results</strong><br></span><span class="fontstyle1">This study included a total of 120 thyroidectomy. The highest frequency of lesions was seen in<br>the fourth and fifth decades (32.74%) with a female predominance (88.38%). Non neoplastic<br>lesions were 106 (88.7%) while neoplastic lesions were 14 (11.7%). Nodular colloid goiter was<br>the commonest non neoplastic lesion while papillary thyroid carcinoma was the most common<br>neoplastic lesion. Follicular adenoma was the most common benign lesion.<br></span><span class="fontstyle0"><strong>Conclusion</strong><br></span><span class="fontstyle1">Histopathological audit, of various thyroid lesions is important both for surgeons and<br>pathologists to make them aware about the common and uncommon thyroid lesions in the<br>setup. Moreover, it can also be used for preventive strategies for various thyroid diseases.<br></span><span class="fontstyle0"><strong>Key words</strong><br></span><span class="fontstyle1">Thyroidectomy, thyroid lesions, neoplastic, thyroiditis, papillary carcinoma</span> </p> 2021-08-19T00:00:00+00:00 Copyright (c) 2021 Advances in Basic Medical Sciences https://abms.kmu.edu.pk/index.php/abms/article/view/166 Antidiabetic, anti-inflammatory and antioxidant activity of Artemisia Roxburghiana along with its qualitative and quantitative phytochemical Screening 2021-08-19T14:54:50+00:00 Sadia Bibi zakhan70@yahoo.co.uk Zahoor Ahmed zakhan70@yahoo.co.uk Shahnaz Dilawar zakhan70@yahoo.co.uk Muhammad Iqbal zakhan70@yahoo.co.uk Shahzad H Sheikh zakhan70@yahoo.co.uk Sumbal Khalid zakhan70@yahoo.co.uk Muhammad Tayyab Ahmad zakhan70@yahoo.co.uk <p><strong>Objective</strong></p> <p>&nbsp;The objective of study was to conduct different assays for exploring pharmacological properties of medicinal plant <em>Artemisia roxburghiana</em> along with its phytochemical screening.</p> <p><strong>Methodology</strong></p> <p><span class="fontstyle0">Qualitative and quantitative tests phytochemical were carried out using different methods for<br>total phenolic and flavonoid contents. Antioxidants capacity, total reducing power assay (TRP) and total antioxidant capacity (TAC) were determined. Formalin induced right hand paw edema method was used for investigation of anti-inflammatory activity. The anti-diabetic study was done by both in-vitro (α amylase inhibition assay) and in-vivo (Alloxan induced anti-diabetic study).</span><strong> <br> </strong></p> <p><strong>Results</strong></p> <p><span class="fontstyle0">The plant revealed the presence of active primary and secondary phytochemicals and exhibits significant anti-oxidant, anti-diabetic and anti-inflammatory activities. Radial scavenging activity (2, 2’-Diphenyl Picrylhydrazyl radical scavenging activity), total antioxidant capacity (TAC), and total reducing power (TRP) of </span><span class="fontstyle2">Artemisia roxburghiana </span><span class="fontstyle0">extracts at final concentration of 400 μg/mL is considerably significant. The presence of alkaloids, phenolic, flavonoids, terpenoids, reducing sugars, glycosides, steroids, carbohydrates and steroids was seen in all the extracts as well as effects of amylase etc.</span><strong> <br> </strong></p> <p><strong>Conclusion</strong></p> <p><span class="fontstyle0">This plant is a source of valuable natural products for pharmaceutical industries and can be<br>used for identification and isolation of novel compounds which leads toward drug discovery for<br>treatment of more serious and complicated diseases.</span><strong><br> </strong></p> <p><strong>Keywords</strong></p> <p>Artemisia, Antidiabetic, DPPH, Antiinflammatory, TAC, Alloxan, Formalin</p> 2021-08-19T00:00:00+00:00 Copyright (c) 2021 Advances in Basic Medical Sciences